IFNA1 and Zika virus infectious disease: Moreover, we detected three possible novel candidate genes involved during this antiviral response: APOL6, XAF1, and TNFRSF1. Finally, we confirmed that IFN signaling dominates the cellular response against ZIKV infection, and that under these conditions, an important contribution is given by apoptotic pathways that might elicit the CZS phenotype (Figure 1).