Urea increases the risk of the primary outcome (CKD ≥ 3) by the odd of 0.309 (69.1%) for any unit increase in urea (95 % C.I.)while high serum anti-PLA2R Ab titre increased the risk of the primary outcome (CKD ≥ 3) by 4.3 odds compared with those subjects with normal serum anti-PLA2R Ab titre. Here, PLA2R1 is linked to chronic kidney disease.