Since insulin resistance is higher in our O-GDM group compared to the N-GDM group, and since it has been shown that insulin resistance associates with increased cholesterol synthesis favoring the production of VLDL, and therefore its metabolization to LDL via the cholesteryl ester transfer protein (an enzyme whose activity increases during pregnancy) [100,101,102], we propose that cholesterol metabolism could be further altered in women of the O-GDM group who were treated with insulin. The gene discussed is INS; the disease is gestational diabetes.