FN1 and esophageal squamous cell carcinoma: Furthermore, increased expression of lncRNA SPRY4-IT1 (sprouty RTK signaling antagonist 4—Intronic Transcript 1) observed in ESCC cell lines increased cell motility and favored EMT, an event strongly related to an increase in the cell motility that could be corroborated by fibronectin-positive staining [141].