Taken together, the analyses of genome-wide TAp73 transcriptional targets indicate a varied role for TAp73 in cancer cell lines dependent on contextual settings, with both p53-like targets being identified as in the focused individual studies, as well as a larger number of genes regulated independent of the p53RE but in association with other transcription factors that are coupled to cellular survival and proliferation. The gene discussed is TP53; the disease is cancer.