It has been demonstrated that different isoforms of transforming growth factor-beta (TGF-β) with immunosuppressive activity are overexpressed in different malignant tumors such as melanoma, gliomas, prostate, gastric, colorectal, ovarian, gastric, and non-small cell lung cancers (NSCLC). The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.