In another study, a single recombinant adenovirus with both interferon-gamma (IFN-γ) and Ii-RGC (rAV/IFN-γ/Ii-RGC) genes efficiently induced the MHC Class II+/Ii- phenotype in MC-38 colon adenocarcinoma cells and Renca tumors. This evidence concerns the gene IFNG and colon adenocarcinoma.