TP53 and neoplasm: Similarly, early tumor onset and shorter overall survival was observed in transgenic mice of Trp53-/R248Q and Trp53R248Q/R248Q genotypes when compared with their Trp53−/− counterparts [25], whereas the Trp53R248W/R248W mice presented more complex tumor spectrum than the Trp53−/− mice, but no significant change in survival [21].