An example of increase in both tumorigenic and metastatic traits resulting from mutated p53 expression was reported by Tan et al. In this work, the presence of p53-R273H (but not p53-R175H) increased AKT1 phosphorylation and suppressed BCL2 modifying factor (BMF) expression, thus increasing cancer cell resistance to apoptosis. The gene discussed is TP53; the disease is cancer.