Interestingly, oncostatin M, an IL-6 superfamily member, was upregulated in patients with rheumatoid arthritis, whereby it was found to increase MMP1, MMP3, and MMP13 through ERK1/2, p38, JNK, and JAK/STAT pathways in chondrocytes [79]. This evidence concerns the gene SOAT1 and rheumatoid arthritis.