As TNFα, IL-1, and IL-6 affect chondrocytes during rheumatoid arthritis development, their intracellular signaling pathways, including NF-ĸB and JAK/signal transducer and activator of transcription (STAT) signaling cascades, play a central role in destruction of cartilage tissues (Figure 1). The gene discussed is SOAT1; the disease is rheumatoid arthritis.