HMGB1 and neoplasm: 5-FU remarkably depletes myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME) [6], and OXP triggers immunogenic cell death (ICD) through the surface exposure of calreticulin (CRT), and the release of high mobility group box 1 (HMGB1) and ATP [5,7], which contribute to recruit CD8+ T cell and induce anti-tumor immunity [8].