Our previous studies indicated a strong correlation between tumor PD-L1 expression and CD8+ tumor-infiltrating lymphocytes (TILs), possibly due to the concomitant increase in interferon γ (IFNγ) expression by CD8+ T cells, and the PD-L1 level is positively correlated with favorable prognosis in CRC patients [10,21]. This evidence concerns the gene IFNG and colorectal carcinoma.