Finally, some IPDs induce thrombocytopenia by reducing the platelet life span, such as changes in glycosylation due to a mutated glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) gene; or impaired function of the ubiquitination, proteasome system in ANKRD26-related thrombocytopenia (ANKRD26-RT) [19,20,21,22]. This evidence concerns the gene GNE and Thrombocytopenia.