By labeling a few proteins, a potential abnormality could be identified or narrowed-down to a group of IPDs featured by cytoskeleton alterations (e.g., FLNA-related thrombocytopenia, FLNA-RT [17], TUBB1-related thrombocytopenia, TUBB1-RT [85], and WAS). This evidence concerns the gene TUBB1 and Thrombocytopenia.