SUMO3 and melanoma: In parallel, we have identified genes associated with super-enhancers using melanoma chromatin immunoprecipitation (ChIP-seq) data [14] and found that >20% of genes that were differentially upregulated in invasive melanoma were also associated with super-enhancers and overlapped with two PPI networks involving the sumoylation protein SUMO3 and polycomb group protein RNF2.