DRAM2 and Abnormal retinal morphology: Three homozygous DRAM2 variants were identified by WES with target analysis of retinal disease-associated genes, viz., c.707_709dup, p.Arg236_Val237insGly in one family (Jikei-176); c.221G>A, p.Arg74His in one family (Kinki-12); and c.8_10delGGT, p.Trp3del in one family (Kinki-69) (Figure 1, Tables S1 and S2).