The influence of Coptidis rhizoma aqueous extract (CRAE) containing 2.2% of MGN, 4.4% palmatine, and 13.8% berberine on vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) has been investigated. This evidence concerns the gene VEGFA and hepatocellular carcinoma.