EGFR and hepatocellular carcinoma: Here, we found that recombinant LZ-8 (rLZ-8) could bind to EGFR specifically, induce catastrophic macropinocytosis, enter into HCC cells with EGFR, lead to the blockage of cell membrane recycling and then result in cell death via membrane ruffling, cell membrane over-internalization, cell rounding and bursting.