To our knowledge, only shRNA-mediated KRAS-knockdown experiments in MM cell lines [10] and overexpression experiments of the exon-2 mutant p.G12V in the MM cell line ANBL6 have been performed, but the latter analysis did not describe the influence on classical survival pathways such as the MEK/ERK- and the PI3K/AKT-pathways [32,33]. Here, MAP2K7 is linked to Miyoshi myopathy.