A recent study has found that DENND1A. V2 might play an important role in pathophysiology of hyperandrogenaemia associated with PCOS [62] due to several reasons: significantly elevated levels of DENND1A. V2 mRNA and protein in PCOS thecal cells compared to non-PCOS thecal cells; significantly elevated levels of DENND1A. V2 mRNA in urine of PCOS women compared to women with normal cycles; augmentation of CYP17A1 and CYP11A1 gene transcription, as well as increased dehydroepiandrosterone production in response to overexpression of DENND1A. V2 in normal thecal cells [63]. This evidence concerns the gene CYP11A1 and polycystic ovary syndrome.