The GluD1 knockout (GluD1-KO) mice line (Grid1tm1Jnz), compared to the relevant control groups, showed abnormal behavioral phenotypes, such as hyper locomotor activity, lower anxiety-like behavior, hyper aggression, higher depression-like behavior, deficits in social interaction [39], enhanced working memory, deficit in contextual and cued fear conditioning [40], and increased stereotyped behavior [41]. Here, GLUD1 is linked to major depressive disorder.