RYR2 and hypertrophic cardiomyopathy: While the vast majority of RyR2 mutations produce hypersensitive channels with increased diastolic SR Ca2+ leak resulting in delayed after-depolarizations, there is a handful of distinct RyR2 mutations including the ARVD2-linked L433P13,37 and the hypertrophic cardiomyopathy-linked A1107M mutation reported to reduce Ca2+ release.27