The first approach, a weighted GRS, was derived from all published independent SLE risk SNPs (Supplementary Material, Table S9)—including 78 SLE susceptibility loci (without the X chromosome), consisting of 93 SNPs outside of the MHC region and 2 independent tag SNPs in the MHC region for two well-known HLA haplotypes in SLE, i.e. rs2187668 for HLA-DRB1*03:01 and rs9267992 for HLA-DRB1*15:01 for the European cohort and rs9271366 for HLA-DRB1/HLA-DQA1 and rs9275328 for HLA-DQB1/HLA-DQA2 for the Chinese cohort (Supplementary Material, Table S9). This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.