TP53 and hepatocellular carcinoma: Giachino et al revealed that NOTCH signalling cooperates with p53 to restrict cell proliferation and tumour growth in mice.29 Conversely, Dill et al reported that constitutive NOTCH2 signalling in mice was sufficient to induce hepatocellular carcinoma and biliary hyperplasia.30 Some researchers have reported that NOTCH2 silencing induced cell cycle arrest at G0/G1 phase in human glioma cells.31, 32 NOTCH2 not only functions in cancer but also regulates the vital events of cardiovascular development.