AKT1 and diabetes mellitus: In this study, STZ-induced diabetic mice were used as models to study the protective effect of mangiferin on diabetic renal interstitial fibrosis injury and to explore the mechanism of the PTEN/PI3K/Akt signaling pathway in mangiferin inhibiting renal interstitial fibrosis in DN, which might be able to provide more theoretical evidence for clinical application of traditional Chinese medicine on treatment of diabetes.