INS and polycystic ovary syndrome: However, some limitations of Daniel et al.'s study should be taken into consideration: (1) a small sample size, including only 10 women with PCOS and 18 controls; (2) only women of normal weight were recruited in that study, without obese women; (3) the EHC, the “gold standard” measure of insulin sensitivity, was not preformed to assess insulin sensitivity in the study population; and (4) the association between adipose IR and cytokines was not studied.