ANGPTL8 and Insulin resistance: In tertiles 2, 3, and 4 of betatrophin, the odds ratios of developing adipose insulin resistance were gradually increased when compared with tertile 1: (95%CI 1.49, 8.82) for tertile 2, (95%CI 4.51, 26.73) for tertile 3, and (95%CI 5.66, 34.82) for tertile 4 vs. tertile 1, p for trend <0.001 (Figure 2(b)).