FBXW7 mutations and amplification of CCNE1 (the gene that encodes cyclin E1) occur in these tumor types (FBXW7 mutations: approximately 1.5% of breast and ovarian cancers; CCNE1 amplification [> 4 copies]: 2.3% in breast cancer, 17.6% in ovarian cancer based on TCGA_B38 data). The gene discussed is CCNE1; the disease is breast cancer.