To understand whether other mechanisms of resistance existed beyond the E2F/G2M/SAC signal identified in NCI-H520R, we generated additional resistance models in tumors of interest to the clinical program including alveolar RMS (SJC-Rh30, Rh41) and ovarian cancer (Kuramochi, OVSAHO, OV90, EFO21) cell lines. The gene discussed is ADCY10; the disease is ovarian cancer.