The subgroup analysis yielded a significant association between a high CD8+ T cell density in intraepithelial or stromal tumour tissue and a favorable OS (intraepithelial, HR 0.320, 95% CI 0.120-0.849, p = 0.002; stromal, HR 0.064, 95% CI 0.016-0.253, p = 0.001; Table 3, ). The gene discussed is CD8A; the disease is neoplasm.