Other genes causing congenital immunodeficiency syndromes that are associated with HLH (e.g., NLRC4, LYST, RAB27A, SH2D1A, XIAP) have not as yet been reported but it is planned to include them in FHLdb in the near future, expanding the data base to a compilation of genetic variants associated to HLH. Here, LYST is linked to hemophagocytic syndrome.