Besides, the deficiency of DSG1 induced by IL-13 might weaken esophageal epithelial integrity, increase periostin and epithelium-secreted TSLP and potentiate EoE, an inflammatory disorder at mucosal epithelium (Sherrill et al., 2014; Davis et al., 2016). This evidence concerns the gene POSTN and eosinophilic esophagitis.