Various studies showed that α4β2 and α7nAChRs were reduced in the cortical and subcortical regions of the brain, including the frontal and temporal cortices, hippocampus, caudate nucleus, and the pons of patients with PD when compared to healthy controls (Lange et al., 1993; Perry et al., 1995; Banerjee et al., 2000). The gene discussed is CHRNA7; the disease is Parkinson disease.