CHRNA7 and Parkinson disease: Based in its neuroprotective effects, and its ability to increase DA levels and positively modulate the α7nAChRs in the brain, we have postulated that cotinine might also delay the development of PD (Soto-Otero et al., 2002; O’Leary et al., 2008; Riveles et al., 2008; Barreto et al., 2014).