TNF and stroke disorder: However, pDCs depletion could induce the pro-inflammatory response under the pathological condition of stroke, including the significantly elevated IL-6, TNF-α concentration (160.17 pg/ml vs. 66 pg/ml in Figure 3A; 605.50 pg/ml vs. 514.37 pg/ml in Figure 3C), and reduced IL-10 level (126.36 pg/ml vs. 185.94 pg/ml in Figure 3B) in plasma of MCAO mice, while the IL-1β concentration had no notable changes (2,258 pg/ml vs. 2,093 pg/ml in Figure 3D).