This is in perfect agreement with findings that Cx43- and Panx-1-based channels participate in the induction of neuroinflammation and cerebral neuropathies (Sarrouilhe et al., 2017; for further considerations on the role of connexins/pannexins in MD, see the section “Inhibited Astrocytic ATP Release in the Pre-frontal Cortex”). This evidence concerns the gene PANX1 and Menkes disease.