For instance, integrative analysis of ChIP-Seq and RNA-Seq data of head and neck squamous cell carcinoma (HNSCC) cell lines showed that cancer-specific histone marks, H3K4me3 and H3K27ac, are associated with transcriptional changes in HNSCC driver genes, epidermal growth factor receptor (EGFR), FGFR1, and FOXA1.4 Zhang et al5 showed the importance of integrating proteomics data along with genomic and transcriptomic data to prioritize driver genes in colon and rectal cancers. This evidence concerns the gene FGFR1 and head and neck squamous cell carcinoma.