KRAS and lung cancer: Although many cell lines were majorly grouped by their cell-of-origin for few cancer types (eg, small-cell lung carcinoma [SCLC], hematopoietic and lymphoid tissue, and breast cancer), several other subgroups were also revealed that were not lineage-dependent and possibly were driven by a shared genetic alteration (eg, cluster 9 which belonged to both non–small-cell lung cancer [NSCLC] and pancreatic cancer cell lines showed prevalent KRAS mutations).39