AKT1 and breast carcinoma: PARADIGM was able to detect the estrogen- and ErbB2-related pathways,36 which were found to be 2 of the 3 key prognostic signatures in breast cancer in a recent major meta-analysis study.66 It is important to note that PARADIGM also identified an AKT1-related PI3K signaling pathway as the top-most pathway with significant IPAs in several samples.