Furthermore, the ability of ML-265-mediated activation of PKM2 to circumvent photoreceptor apoptosis in vivo is in accordance with our previous results that showed decreased apoptosis and improved photoreceptor survival during acute outer retinal stress, as produced by experimental retinal detachment, in the Rho-Cre:Pkm2f/f mouse model with PKM1-expressing photoreceptors15. Here, RHO is linked to retinal detachment.