We observed that the association between LESM with cognitive function persisted after adjusting for age, gender and ethnicity, years of education, depressive symptoms, diabetes duration, stroke, smoking, systolic blood pressure, LDL-cholesterol, HbA1c, body mass index, estimated glomerular filtration rate and log-transformed urinary albumin-to-creatinine ratio, body fat, use of metformin and use of hypolipidemic treatment. The gene discussed is ALB; the disease is stroke disorder.