For example, siRNA targeting the IL-2/IL-15Rβ chain used in adjuvant-induced arthritis in rats was effective in reducing disease severity31 and a small-molecule phenylpyrazoleanilide Y-320 inhibited T cell activation induced with IL-15 and reduced type II collagen-induced arthritis in mice and cynomolgus monkeys32. Here, IL2 is linked to arthritic joint disease.