Many animal models have been developed for studying Sjögren’s syndrome including derivatives of the NOD line, induced models such as Ro or M3R immunized mice, or engineer strains such as STIM1/2 KO, matriptase KO, IL-12 TG, BAFF TG, IL-14α TGPI3K KO, or ID3 KO systemic and T-cell specific models (for review see35). This evidence concerns the gene CALR and Sjogren syndrome.