In a similar assay where tube formation of HUVECs was induced by VEGF plus FGF2, tube formation was partially disrupted by co-culturing with either VEGFR2-Fc– or FGFR2-Fc–expressing tumor cells (Fig. 4a,b), and completely disrupted by co-culturing with a mixture of VEGFR2-Fc– and FGFR2-Fc–expressing tumor cells (Fig. 4a,b; Supplementary Fig. 6a,b). Here, KDR is linked to neoplasm.