To examine the roles of the FGF signaling in in vivo tumor growth of VEGFR2-Fc–expressing tumors, we established Renca and B16F10 tumor cells overexpressing FGFR2-Fc (the extracellular domain of mouse FGFR2 fused to the Fc region of human IgG4) (Supplementary Fig. 5a). Here, KDR is linked to neoplasm.