FGFR4 and neoplasm: However, we also found that the mRNA levels of Fgfr3 in the Renca model and Fgfr1 and Fgfr4 in the B16F10 model were significantly upregulated by chronic expression of VEGFR2-Fc (Fig. 2c,d), consistent with previous reports that FGFR1, 3, and 4 also play a critical role in tumor angiogenesis26,27.