Using the breast cancer cell lines of the Cancer Cell Line Encyclopedia (CCLE), the stathmin mRNA signature score was significantly associated with our vascular proliferation score, VEGF expression, hypoxia scores (Hu 2009 and Halle 2012)34,35, PD-L1 expression and the nestin mRNA signature score (all p < 0.001; Supplementary Fig. S5a–f). This evidence concerns the gene NES and cancer.