We should further attempt to integrate all potential pathways related to circulatory perfusion, including the renin-angiotensin-aldosterone system, serum/urine osmolality, vasopressin and other relevant indicators (e.g., vasopressinase, copeptin, oxytocinase, and leucyl-cystinyl aminopeptidase), and behavioral factors (e.g., salt intake)11–13,28–31 to prevent preeclampsia. Here, REN is linked to preeclampsia.