The number of foot slips performed by HX-EE MyRF(fl/fl) mice was not significantly different than HX MyRF(+/+) mice (2-cm: 3.9 ± 0.2 slips vs. 3.2 ± 0.2; 1-cm: 5.2 ± 0.3 vs. 5.6 ± 0.3), indicating that blocking de novo oligodendrogenesis completely prevents EE-induced functional recovery from perinatal brain injury. The gene discussed is MYRF; the disease is brain injury.