In this study, we analyzed human fibroblasts from skin biopsy samples of two sibling X-ALD patients with an identical mutation on the ABCD1 gene (c1825G>A); one X-ALD fibroblast was from a patient with CCALD phenotype, and the other X-ALD fibroblast was from a patient with AMN phenotype. This evidence concerns the gene ABCD1 and adrenomyeloneuropathy.