TG2 regulates the activity of substrate proteins in response to various stressors through polyamination, crosslinking, or deamidation modification, conferring a growth advantage on cancer cells (Han & Park, 1999; Mehta et al, 2004; Fok et al, 2006; Herman et al, 2006; Verma et al, 2006). Here, TGM2 is linked to cancer.