TG2 is also involved in tumor cellular function: tumor cells under hypoxic stress exhibit an HIF1-dependent increase in TG2 expression and intracellular activity (Jang et al, 2010), and, in a mouse xenograft model, TG2-depleted tumor cells show reduced cell growth and viability (Jang et al, 2010). Here, TGM2 is linked to neoplasm.