In particular, the expression of pentraxin-3 (PTX3), reported to regulate the inflammatory activity of macrophages (Shiraki et al., 2016), as well as IL-6 and IP-10/CXCL10, known indicators of the inflammatory status in HIV infection (de Medeiros et al., 2016), was higher in the lymph nodes of animals infected with the mutant virus than in those infected with WT SIVmac239 (Figure 3B). The gene discussed is PTX3; the disease is HIV infectious disease.