Irregular shapes of nuclei had been reported in the neural precursor cells and hippocampal neurons of PD patients carrying PD-related LRRK2 G2019S mutation [18, 19] and in the midbrain dopaminergic neurons of transgenic mice with ectopic expression of PD-related LRRK2 R1441C mutation [20]. The gene discussed is LRRK2; the disease is Parkinson disease.