1, 7, 11, 20, and 22 interconnect to one of the top-scoring schizophrenia risk loci, MAD1L1 [56], which in context of reward-associated paradigms is associated with significant functional hypoactivation of the ventral midbrain and its prefrontal targets [88], to multiple genes each located within 40 kb from both BMI and SCZ risk sequences, such as, (i) chr. The gene discussed is MAD1L1; the disease is schizophrenia.