Strikingly, however, the 11 EHs, comprised of chromatin domains shared by BMI and schizophrenia GWAS, include 339 risk genes with functional enrichment for lipid regulation, axon guidance and dopaminergic signaling, reward and addiction pathways, starvation response, and signaling cascades linked to BDNF, a neurotrophic factor representing a key molecule for synaptic plasticity and regulation of food intake and body weight by modulating MDN activity including their (dopaminergic) fiber projections into the forebrain [80] (Fig. 2e, f, Additional file 2: Table S7). The gene discussed is NT5M; the disease is schizophrenia.