CFL1 and cancer: These findings support a hypothetical model of arnidiol-mediated apoptosis in cancer cells in which arnidiol-induced ROCK1 activation represents a primary event resulting in the dephosphorylation of Drp1 (Ser637) and cofilin (Ser3), leading, in turn, to the mitochondrial translocation of Drp1 and cofilin and culminating in mitochondrial fission and apoptosis.