HTR2B and carcinoid syndrome: Given the known risks of valvulopathy associated with carcinoid syndrome [31] and pergolide, [2] the effects of cabergoline on the 5HT-2B receptor, as well as conflicting findings in the existing literature, even larger additional studies with longer-term exposure of observed daily doses are needed among more contemporary, ethnically diverse populations to confirm our findings, to address the risk associated with different thresholds of cumulative cabergoline exposure, and to examine their potential long-term clinical significance.