Between sepsis patients and controls, we found significant differences in the serum concentrations of the following eight metabolites: glucose (median concentration 5.63 mmol/l vs 4.13 mmol/l, p < 0.01), citrate (0.08 mmol/l vs 0.10 mmol/l, p < 0.01), glycine (0.43 mmol/l vs 0.31 mmol/l, p < 0.001), histidine (0.07 mmol/l vs 0.08 mmol/l, p < 0.05), 3-hydroxybutyrate (0.15 mmol/l vs 0.11 mmol/l, p < 0.01), creatinine (0.11 mmol/l vs 0.05 mmol/l, p < 0.001), and glycoprotein acetyls (mainly alpha−1-acid glycoprotein, AGP) (1.81 mmol/l vs 1.34 mmol/l, p < 0.001) (Table 2). Here, ART4 is linked to Sepsis.