AKT1 and breast cancer: Compounds 204 and 199 displayed potential in suppressing breast cancer cell (MDA-MB-231) migration, with nanomolar IC50 values of 337 and 60 nM, and blocked cell proliferation, with micromolar IC50 values of 12.7, and 2.8 μM, by inactivating the expression of focal adhesion kinase (FAK), p-FAK, Akt, and p-Akt through the β-1 integrin-mediated antimetastatic pathway [154].