MMP2 and cancer: Based on our KLF2 knockdown and overexpression data, the phenotype induced by miR-BART17-5p may be due to the decreased expression of KLF2. Previous reports showed that KLF2 suppressed anchorage-independent growth by inhibiting the expression of Gli1 in liver cancer [56] as well as migration by inhibiting MMP2, N-cadherin, and vimentin in several cancers [48,49].