Since KLF2 is silenced by EZH2 in GC [27], increased expression of EZH2 in EBVaGC may have silenced KLF2. Li et al. [59] reported that Helicobacter pylori (H. pylori) induced miR-25 to reduce the expression of KLF2. As GC can be co-infected with EBV and H. pylori, both miR-25 and miR-BART17-5p may exert a simultaneous effect on the expression of KLF2. It is not clear which pathway would be more important for the development of GC based on our data, as we did not test the effect of H. pylori infection. Here, EZH2 is linked to gastric cancer.