RHOA and neoplasm: Furthermore, cell-autonomous effects of mutant p53 on receptor tyrosine kinase expression (EGFR, PDGFRβ, and MET); Myo10-mediated integrin transport; spatial regulation of RhoA; RCP-dependent endocytic trafficking; and ENTPD5-mediated N-glycoprotein-folding further increase the migratory and invasive propensity of tumor cells [23].