Under conditions of hypoxia, p53 mutants accumulating in late-stage non-small cell lung cancer (NSCLC) were found to assemble into a complex with HIF1, which binds to the SWI/SNF chromatin remodeling complex to promote the expression of a subset of hypoxia-responsive HIF1 target genes [163]. Here, TP53 is linked to non-small cell lung carcinoma.