Of these proteins, several have well-defined tumor-related functions in ECM modulation (MMP1, MMP13, TIMP-3, and MMP2); tumor cell survival (BDNF, FGF-4, and IGFBPs); regulation of immune responses (B-2M, IL-8, and attractin); cell-cell communication (α-catenin and β-5 tubulin); angiogenesis (VEGF, PEDF, and CYR61); and the cell migration-invasion-metastasis cascade (ADAM-10, TGF-β, Tau, and MMPs) [104]. The gene discussed is BDNF; the disease is neoplasm.