Along the same line, treatment of hepatocellular carcinoma cells with Mdm2 inhibitors activated p53-mediated gene expression and protein secretion of steroid hormone binding factors, such as SHBG (sex hormone-binding globulin) and CBG (corticosteroid-binding globulin), capable of promoting apoptosis in breast cancer cells [105]. This evidence concerns the gene SHBG and hepatocellular carcinoma.