SREBF1 and metabolic dysfunction-associated steatotic liver disease: Nrf2 activation triggers antioxidant defenses against the oxidative stress prevailing NAFLD [33,57], which may avoid (i) further n-3 LCPUFA depletion that favors steatosis development; and (ii) the induction of endoplasmic reticulum (ER) stress through protein oxidation/unfolding that upregulates lipogenic SREBP-1c and PPAR-γ expression [58].