PPARA and metabolic dysfunction-associated steatotic liver disease: Notably, liver SREBP-1c upregulation, PPAR-α downregulation, and depletion of n-3 LCPUFA are also observed in obese patients with NAFLD, the respective SREBP-1c/PPAR-α ratios being inversely correlated with the n-3 LCPUFA levels and directly associated with insulin resistance [55].